TB Diagnostic Reference Documents

• Organized by topic

• Organized by source

Organized by Topic

Epidemiology & Surveillance
TB Diagnosis — Active Disease
TB Diagnosis — Latent Disease/Exposure/Screening
TB Therapy — Active Disease
TB Therapy — Latent Disease
TB and HIV
Directly Observed Therapy (DOTS)
TB Control Policy
TB in Children
Special Groups & Vulnerable Populations

Epidemiology & Surveillance
WHO Global TB Report 2005.   Produced by the WHO.
Epidemiologic Basis of Tuberculosis Control [1999] (PDF). Produced by the IUATLD.
EuroTB : European recommendations on TB surveillance.   Surveillance of tuberculosis in Europe [1996].   Produced by EuroTB.

TB Diagnosis — Active Disease
Diagnostic Standards and Classification of Tuberculosis in Adults and Children [1999] (PDF).   Produced by the American Thoracic Society.
Rapid Diagnostic Test for Tuberculosis: What is the Appropriate Use? [1997] (PDF). Produced by the American Thoracic Society.

TB Diagnosis — Latent Disease/Exposure/Screening
Guidelines for the Diagnosis of Latent TB (UMDNJ). Produced by the University of Medicine and Dentistry of New Jersey (UMDNJ),    this document discusses targeted tuberculin skin testing for latent TB infection as a strategic component of TB control.
Targeted Tuberculin Testing and Treatment of Latent Tuberculosis Infection [1999].Produced by the American Thoracic Society.
Guidelines for Using the QuantiFERON  ®-TB Test for Diagnosing Latent Mycobacterium tuberculosis Infection [2003] (PDF).   Produced by the CDC.
Screening for Tuberculosis Infection [1996] (PDF). Produced by the US Preventative Services Task Force.
Guidelines for Targeted Skin Testing and Treatment of Latent TB Infection in Adults and Children [2002]. Produced by the CDHS/CTCA.
Contact Investigation Guidelines [1998]. Produced by the CDHS/CTCA.

TB Therapy — Active Disease
Treatment of TB: Standard Therapy for Active Disease in Adults.   Produced by   UMDNJ.
Standard Therapy for Active Disease in Children and Adolescents.   Produced by UMDNJ.
Treatment of Tuberculosis guidelines for national programmes – Third edition [2003].Produced by the WHO.
Revised Chapter 4 from the: Treatment of Tuberculosis: Guidelines for National Programmes.Third edition [2003].   Produced by the WHO.
Treatment of Tuberculosis. American Thoracic Society, CDC, and Infectious Diseases Society of America [2002].   Produced by the American Thoracic Society.
Chemotherapy and management of tuberculosis in the United Kingdom: recommendations [1998] (PDF). Produced by the British Thoracic Society.
Practice Guidelines for the Treatment of Tuberculosis [2000] (PDF). Produced by the Infectious Diseases Society of America.
Treatment of Tuberculosis and Tuberculosis Infection in Adults & Children [1994] (PDF). Produced by the American Thoracic Society.
Guidelines for the Treatment of Active Tuberculosis Disease [2003]. Produced by the CDHS/CTCA.

TB Therapy — Latent Disease
Targeted Tuberculin Testing and Treatment of Latent Tuberculosis Infection [1999]Produced by the American Thoracic Society/CDC.
Adverse Event Data and Revised American Thoracic Society/CDC Recommendations Against the Use of Rifampin and Pyrazinamide for Treatment of Latent Tuberculosis Infection [2003] (PDF).   Produced by the ATS/CDC.
Guidelines for Targeted Skin Testing and Treatment of Latent TB Infection in Adults and Children [2002]. Produced by the CDHS/CTCA.

TB and HIV
Treatment of TB in Adults and Adolescent Patients Co-Infected with HIV.   Produced by UMDNJ.
TB/HIV Clinical Manual, 2nd Ed [2004] (PDF).Produced by the WHO.
Guidelines for HIV surveillance among tuberculosis patients 2nd Ed [2004] (PDF).Produced by the WHO.
Policy Statement on Preventive Therapy Against Tuberculosis in People Living with HIV [1998] (PDF).Produced by the WHO.
A strategic frameworkto decrease the burden of TB/HIV [2002] (PDF).   Produced by the WHO.
Interim policy on collaborative TB/HIV activities [2004] (PDF).Produced by the WHO.
A guide to monitoring and evaluation for collaborative TB/HIV activities [2004] (PDF).Produced by the WHO.
Anergy Skin Testing and Preventive Therapy for HIV-Infected Persons: Revised Recommendations. [1997] (PDF).   Produced by the CDC.
Updated Guidelines for the Use of Rifamycins for the Treatment of Tuberculosis Among HIV-Infected Patients Taking Protease Inhibitors or Nonnucleoside Reverse Transcriptase Inhibitors [2004] (PDF).   Produced by the CDC.
TB-HIV:A Guide for Health Worker (PDF).Produced by the Revised National TB Control Program, India.

Directly Observed Therapy (DOTS)
Combating Tuberculosis: Principles for Accelerating DOTS coverage [1999]. Produced by the WHO.
An Expanded DOTS Framework for effective Tuberculosis Control [2002] (PDF).
DOTS-Plus:    preliminary results and emerging issues [2002] (PDF).   Produced by the WHO.
What is DOTS? – A guide to understanding the WHO-recommended TB control strategy known as DOTS [1999] (PDF).   Produced by the WHO.
Directly Observed Therapy Program Protocols in California [1997]. Produced by the CDHS/CTCA.

Drug-resistance
Anti-Tuberculosis Drug Resistance in the World [2004] (PDF).   Produced by the WHO.
Multidrug resistant tuberculosis (MDR-TB): Basis for the development of an evidence-based case-management strategy for MDR-TB within the WHO’s DOTS strategy [1999] (PDF).   Produced by the WHO.
Guidelines for the management of drug-resistant TB [1997] (PDF).Produced by the WHO.
Management of Persons Exposed to Multidrug-Resistant Tuberculosis [1992] (PDF).Produced by the CDC.

TB Control Policy
Global Plan to Stop TB [2003] (PDF).   Produced by the WHO.
Involving Private Practitioners in Tuberculosis Control [2001] (PDF).   Produced by the WHO.
Guidelines for conducting a review of a national tuberculosis programme [1998] (PDF).Produced by the WHO.
European framework to decrease the burden of TB/HIV [2003] (PDF).   Produced by the WHO.
European framework for tuberculosis control and elimination in countries with a low incidence [2002].   Produced by the WHO.
Control of tuberculosis in the United States [1992]. Produced by the American Thoracic Society.

Tuberculosis in Children
Consensus Statement on Diagnosis of Childhood Tuberculosis [2004]. Produced by the Indian Academy of Pediatrics.

Special Groups & Vulnerable Populations
Prevention and Control of Tuberculosis in Correctional Facilities [1996] (PDF).
TB control in refugee situations [1997] (PDF).   Produced by the WHO.
Guidelines for the control of TB in prisons [1998] (PDF).   Produced by the WHO.
Guidelines for the Placement or Return of Tuberculosis Patients into High Risk Housing, Work, Correctional or In-Patient Settings [1997]. Produced by the CDHS/CTCA.
Tuberculosis Screening Guidelines for Drug Treatment Programs in California [1997].Produced by the CDHS/CTCA.
Guidelines for the Civil Detention of Persistently Non-Adherent Tuberculosis Patients in California [1999].   Produced by the CDHS/CTCA.
Guidelines for Coordination of TB Prevention and Control by Local and State Health Departments and California Department of Corrections [1998].Produced by the CDHS/CTCA.

Health care workers & nosocomial, occupational transmission
Guidelines for Workplace TB Control [2003] (PDF).   Produced by the WHO.
Guidelines for the prevention of    tuberculosis in health care facilities in resource-limited settings [1999] (PDF).Produced by the WHO.
Guidelines for Screening Employees and Residents of Skilled Nursing Facilities [2001]. Produced by the CDHS/CTCA.
A Guideline for Establishing Effective Practices: Identifying Persons with Infectious TB in the Emergency Department [1999] (PDF). Produced by the Francis J. Curry National TB Center, San Francisco.
Policy and Procedures for Tuberculosis Screening of Healthcare Workers [1999] (PDF). Produced by the Francis J. Curry National TB Center, San Francisco.

Laboratory Manuals
Laboratory services in tuberculosis control: Part I:    Organization and Management [1998] (PDF).   Produced by the WHO.
Laboratory services in tuberculosis control: Part II:    Microscopy [1998] (PDF).Produced by the WHO.
Laboratory services in tuberculosis control: Part III:    Culture [1998] (PDF).   Produced by the WHO.

For the Families of TB Patients
A guide for Tuberculosis Treatment Supporters [2002] (PDF).   Produced by the WHO.

Diagnosis and Treatment of Nontuberculous Mycobacteria
Diagnosis and Treatment of Disease Caused by Nontuberculous Mycobacteria [1997] (PDF)

TB — Multiple Topics
Toman’s Tuberculosis: Case detection, treatment and monitoring, 2nd Ed [2004] (PDF).Produced by the WHO.
Tuberculosis handbook [1998] (PDF).   Produced by the WHO.
Tuberculosis Control: an Annotated Bibliography [2001].   Produced by the WHO.
Core Curriculum on Tuberculosis, 4th Ed [2000] (PDF).   Produced by the CDC.

Organized by Source

American Thoracic Society
British Thoracic Society
Canadian Lung Association, Canadian Thoracic Society & Centre for Infectious Disease Prevention, Health Canada
CDHS/CTCA Joint Guidelines (California Dept of Health Services & California TB Controllers Association)
Centers for Disease Control (CDC)
Department of Health, UK
Dept of Human Services, Victoria, Australia
EuroTB
European Respiratory Society
Francis J Curry National TB Center, San Francisco
Georgia Division of Public Health
Global Health Council
Indian Academy of Paediatrics
Infectious Diseases Society of America (IDSA)
Institute of Medicine, USA
International Union Against Tuberculosis and Lung Disease
New Zealand Ministry of Health
Revised National Tuberculosis Control Program, India
Sociedad Argentina de Pediatrà­a. Comità© Nacional de Neumonologà­a y Comità© Nacional de Infectologà­a
University of Medicine and Dentistry of New Jersey (UMDNJ)
US Preventive Services Task Force
World Health Organization (WHO)

American Thoracic Society
Treatment of Tuberculosis. American Thoracic Society, CDC, and Infectious Diseases Society of America [2002]   
Targeted Tuberculin Testing and Treatment of Latent Tuberculosis Infection [1999]
Diagnostic Standards and Classification of Tuberculosis in Adults and Children [1999] (PDF)
Diagnosis and Treatment of Disease Caused by Nontuberculous Mycobacteria [1997] (PDF)
Rapid Diagnostic Test for Tuberculosis: What is the Appropriate Use? [1997] (PDF)
   Institutional Control Measures for Tuberculosis in the Era of Multiple Drug Resistance [1995] (PDF)
Treatment of Tuberculosis and Tuberculosis Infection in Adults & Children [1994] (PDF)
Control of tuberculosis in the United States [1992]
Guidelines for the Treatment of Active Tuberculosis Disease [2003]

British Thoracic Society
Control and prevention of tuberculosis in the United Kingdom: Code of Practice [2000] (PDF)
Management of opportunist mycobacterial infections: Joint Tuberculosis Committee guidelines 1999 [2000] (PDF)
Chemotherapy and management of tuberculosis in the United Kingdom: recommendations [1998] (PDF)

CDHS/CTCA Joint Guidelines (California Dept of Health Services & California TB Controllers Association)
Guidelines for the Treatment of Active Tuberculosis Disease [2003]
Guidelines for Targeted Skin Testing and Treatment of Latent TB Infection in Adults and Children [2002]
California Tuberculosis Controllers Association QuantiFERON Position Statement [2003]
Guidelines for Mycobacteriology Services in California [1997]
Directly Observed Therapy Program Protocols in California [1997]
TB Case Management – Core Components [1998]
Guidelines for the Follow-Up and Assessment of Persons with Class B1/B2 Tuberculosis [1999]
Guidelines for the Placement or Return of Tuberculosis Patients into High Risk Housing, Work, Correctional or In-Patient Settings [1997]
Tuberculosis Screening Guidelines for Drug Treatment Programs in California [1997]
Guidelines for the Civil Detention of Persistently Non-Adherent Tuberculosis Patients in California [1999]
Guidelines for Coordination of TB Prevention and Control by Local and State Health Departments and California Department of Corrections [1998]
Contact Investigation Guidelines [1998]
Source Case Investigation Guidelines [2001]
Guidelines for Screening Employees and Residents of Skilled Nursing Facilities [2001]
Guidelines for Reporting Tuberculosis Suspects and Cases in California [1997]

Canadian Lung Association, Canadian Thoracic Society & Centre for Infectious Disease Prevention, Health Canada
Canadian Tuberculosis Standards. 5th Edition [2000] (PDF)
Guidelines for the investigation and follow-up of individuals under medical surveillance for tuberculosis after arriving in Canada: a summary. [2003]

Centers for Disease Control (CDC)
Core Curriculum on Tuberculosis, 4th Ed [2000] (PDF).
Anergy Skin Testing and Preventive Therapy for HIV-Infected Persons: Revised Recommendations. [1997] (PDF).
The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States [1996] (PDF).
Progressing Toward Tuberculosis Elimination in Low-Incidence Areas of the United States [2002] (PDF).
Tuberculosis Elimination Revisited: Obstacles, Opportunities, and a Renewed Commitment [1999] (PDF).
Essential Components of a Tuberculosis Prevention and Control Program [1995] (PDF).
Recommendations for Prevention and Control of Tuberculosis among Foreign-Born Persons [1998] (PDF).
Prevention and Control of Tuberculosis in Correctional Facilities [1996] (PDF).
Screening for Tuberculosis and Tuberculosis Infection in High-Risk Populations [1995] (PDF).
Prevention and Control of Tuberculosis Among Homeless Persons [1992] (PDF).
Guidelines for Environmental Infection Control in Health-Care [2003] (PDF).
Guidelines for Preventing the transmission of Mycobacterium tuberculosis in Health-Care Facilities [1994] (PDF).
National Action Plan to Combat Multidrug-Resistant Tuberculosis [1992] (PDF).
Management of Persons Exposed to Multidrug-Resistant Tuberculosis [1992] (PDF).
Guidelines for Using the QuantiFERON  ®-TB Test for Diagnosing Latent Mycobacterium tuberculosis Infection [2003] (PDF).
Updated Guidelines for the Use of Rifamycins for the Treatment of Tuberculosis Among HIV-Infected Patients Taking Protease Inhibitors or Nonnucleoside Reverse Transcriptase Inhibitors [2004] (PDF).
Adverse Event Data and Revised American Thoracic Society/CDC Recommendations Against the Use of Rifampin and Pyrazinamide for Treatment of Latent Tuberculosis Infection [2003] (PDF).

Department of Health, UK
Stopping tuberculosis in England [2004] (PDF)

Dept of Human Services, Victoria, Australia
Management, prevention and control of tuberculosis: Guidelines for health care providers 2002-2005 (PDF)

EuroTB
EuroTB : European recommendations on TB surveillance: Surveillance of tuberculosis in Europe [1996]
Standardisation of antituberculosis drug resistance surveillance in Europe
Standardised tuberculosis treatment outcome in Europe

European Respiratory Society
Tuberculosis management in Europe. Task Force of the European Respiratory Society (ERS), the World Health Organisation (WHO) and the International Union against Tuberculosis and Lung Disease (IUATLD) Europe Region [1999]

Francis J Curry National TB Center, San Francisco
A Guideline for Establishing Effective Practices: Identifying Persons with Infectious TB in the Emergency Department [1999] (PDF)
Policy and Procedures for Tuberculosis Screening of Healthcare Workers [1999] (PDF)
Treating Latent Tuberculosis Infection in Key High-Risk Communities

Georgia Division of Public Health
Tuberculosis Reference Guide [2001] (PDF)

Global Health Council
Research Brief “Preventing Tuberculosis in HIV-infected Persons† [2004] (PDF)
Evidence for Action: Lack of Evidence that Directly Observed Therapy (DOT) Improves Cure or Treatment Completion Rates in Patients with Tuberculosis [2001]

Indian Academy of Paediatrics
Consensus Statement on Diagnosis of Childhood Tuberculosis [2004]

Infectious Diseases Society of America (IDSA)
Practice Guidelines for the Treatment of Tuberculosis [2000] (PDF)

Institute of Medicine, USA
Tuberculosis in the workplace [2001] (PDF)
Ending Neglect: Elimination of tuberculosis in the US [2000] (PDF)

International Union Against Tuberculosis and Lung Disease
Management of Tuberculosis: a Guide for Low Income Countries [2000] (PDF)
Technical Guide: Sputum Examination for Tuberculosis by Direct Microscopy in Low Income Countries [2000] (PDF)
Interventions for Tuberculosis Control and Elimination    [2002] (PDF)
Tuberculosis A Manual for Medical Students [2003] (PDF)
A Tuberculosis Guide for Specialist Physicians – part 1 [2004] (PDF)
A Tuberculosis Guide for Specialist Physicians – part 2 [2004] (PDF)
A Tuberculosis Guide for Specialist Physicians – part 3 [2004] (PDF)
Epidemiologic Basis of Tuberculosis Control [1999] (PDF)
The Public Health Service National Tuberculosis Reference Laboratory and the National Laboratory Network [1998] (PDF)
Tuberculosis Programs Review, Planning, Technical Support: A manual of methods and procedures [1998] (PDF)

New Zealand Ministry of Health
Guidelines for Tuberculosis Control in New Zealand [2003] (PDF)
DOTS for tuberculosis [2001] (PDF)

Revised National Tuberculosis Control Program, India
Technical Guidelines for Tuberculosis Control [2000] (PDF)
Operational Guidelines for Tuberculosis Control [2000] (PDF)
TB-HIV:A Guide for Health Worker (PDF)
Consensus statement of management of Pediatric TB under RNTCP [2003](PDF)
NGO Guidelines (PDF)
A guide for practicing physicians   
A guide for medical officers

Sociedad Argentina de Pediatrà­a. Comità© Nacional de Neumonologà­a y Comità© Nacional de Infectologà­a
Criterios de diagn óstico y tratamiento de la tuberculosis infantil / Diagnostic and therapeutic criteria for the management of tuberculosis in childhood [2002] (PDF)

University of Medicine and Dentistry of New Jersey (UMDNJ)
Guidelines for the Diagnosis of Latent TB (UMDNJ). Produced by the University of Medicine and Dentistry of New Jersey (UMDNJ),    this document discusses targeted tuberculin skin testing for latent TB infection as a strategic component of TB control.
Treatment of TB: Standard Therapy for Active Disease in Adults.   Produced by the University of Medicine and Dentistry of New Jersey (UMDNJ), this document is a pocket-sized guide that provides information on the standard therapy of TB for active TB disease.
Standard Therapy for Active Disease in Children and Adolescents.   Produced by the University of Medicine and Dentistry of New Jersey (UMDNJ), this document is a pocket-sized guide that provides information on the standard therapy of TB for active TB disease, specifically for children and adolescents.
Treatment of TB in Adults and Adolescent Patients Co-Infected with HIV.   Produced by the University of Medicine and Dentistry of New Jersey (UMDNJ), this document provides information on TB treatment for patients co-infected with HIV who are on highly active anti-retroviral therapy (HAART).
Management of latent tuberculosis infection in children [2004] (PDF)
Guidelines for Initiating a School-Based Directly Observed Therapy Program [2002]   
Treating the Patient with Tuberculosis: Guidelines for Collaborating with Community Physicians [2003]

US Preventive Services Task Force
Screening for Tuberculosis Infection [1996] (PDF)

World Health Organization
WHO Global TB Report 2005
Combating Tuberculosis: Principles for Accelerating DOTS coverage [1999]
An Expanded DOTS Framework for effective Tuberculosis Control [2002] (PDF)
Toman’s Tuberculosis: Case detection, treatment and monitoring, 2nd Ed [2004] (PDF)
TB/HIV Clinical Manual, 2nd Ed [2004] (PDF)
Guidelines for HIV surveillance among tuberculosis patients 2nd Ed [2004] (PDF)
Guidelines for surveillance of drug resistance in tuberculosis [2003] (PDF)
Treatment of Tuberculosis guidelines for national programmes – Third edition [2003]
Revised Chapter 4 from the: Treatment of Tuberculosis: Guidelines for National Programmes.Third edition [2003]
A guide for Tuberculosis Treatment Supporters [2002] (PDF)   
Guidelines for Workplace TB Control [2003] (PDF)
Anti-Tuberculosis Drug Resistance in the World [2004] (PDF)
DOTS-Plus:    preliminary results and emerging issues [2002] (PDF)
Global Plan to Stop TB [2003] (PDF)
Public-Private Mix for DOTS:    Practical tools to help implementation [2003] (PDF)
Involving Private Practitioners in Tuberculosis Control [2001] (PDF)
What is DOTS? – A guide to understanding the WHO-recommended TB control strategy known as DOTS [1999] (PDF)
Guidelines for the prevention of    tuberculosis in health care facilities in resource-limited settings [1999] (PDF)
Multidrug resistant tuberculosis (MDR-TB): Basis for the development of an evidence-based case-management strategy for MDR-TB within the WHO’s DOTS strategy [1999] (PDF)
Tuberculosis handbook [1998] (PDF)
Guidelines for conducting a review of a national tuberculosis programme [1998] (PDF)
Policy Statement on Preventive Therapy Against Tuberculosis in People Living with HIV [1998] (PDF)
A strategic frameworkto decrease the burden of TB/HIV [2002] (PDF)
Interim policy on collaborative TB/HIV activities [2004] (PDF).   
TB control in refugee situations [1997] (PDF).
Guidelines for the control of TB in prisons [1998] (PDF).
Guidelines for the management of drug-resistant TB [1997] (PDF).
Tuberculosis Control: an Annotated Bibliography [2001].
European framework to decrease the burden of TB/HIV [2003] (PDF).
European framework for tuberculosis control and elimination in countries with a low incidence [2002].
A guide to monitoring and evaluation for collaborative TB/HIV activities [2004] (PDF).
Laboratory services in tuberculosis control: Part I:    Organization and Management [1998] (PDF).
Laboratory services in tuberculosis control: Part II:    Microscopy [1998] (PDF).
Laboratory services in tuberculosis control: Part III:    Culture [1998] (PDF).